Phenylpropanolamine has an excellent bioavailability for both controlled-release and immediate-release formulations (93.7% and 98%, respectively) in dogs. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. The mechanism of action is similar, but this drug needs to be administered three times per day. Evaluation of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch. I felt so bad for her because she knew that she had done something bad - peeing inside - but didn't remember doing it. Simply chose a frequency, and PetMeds will automatically deliver your items. What is Incurin (Estriol) 1 mg, 30 Tablets? Incurin is another FDA-approved Rainey was on DES for 5 years with 0 side effects. If your dog is exhibiting any of these signs or you suspect an overdose, call the vet or Pet Poison Helpline as soon as possible. Since Proin increases thirst, make sure your dog has ample fresh water within easy reach while supplementing. Safety studies performed by the manufacturer showed that dosing at up to 5 times the recommended dose for 6 months resulted in hypertension; however, the mean arterial pressure was not significantly different than that in the ideal dosing group and no evidence of target organ damage was noted at necropsy. -- Ernest Hemmingway, http://www.leospetcare.com/incurin-estriol-is-not-the-same-as-ovaban-des/. 21. Copyright 2023 PetMed Express, Inc. All Rights Reserved. is an adrenergic agent that activates the adrenal receptors, similar mechanism of action like epinephrine and norepinephrine. Mechanism of estrogen agonists and antagonists. The information is NOT to be used for diagnosis or treatment of your pet. 5. Before starting to use Proin, inform your veterinarian about any medication your dog is taking, including supplements, vitamins, and herbal remedies. Note: Any trademarks are the property of their respective companies. In talking to the vet office, they dont put dogs are both - their policy not specific to my dog. PROIN ERTM. 39, 69-72. 22. In extra sensitive dogs, Proin may trigger an allergic reaction with symptoms like hives, facial swelling (lips, tongue), and breathing difficulties. I had switched her to a new practice that was closer to home. In other words, Pehnylpropranolamine works by constricting the bladder sphincter muscle, thus preventing urine leakage. Hmm, good input - thank you! Urethral sphincter mechanism incompetence (USMI) is the most common cause of urinary incontinence in spayed female dogs.1 Studies have estimated the prevalence of USMI in dogs to be between 5.1% and 20%, with large-breed dogs being predisposed.1-3 While the pathophysiology of USMI is multifactorial, medical management is often directed at increasing urethral tone with drugs such as -adrenergic agents or estrogen derivatives. Please enable JavaScript in order to continue using our website. I've bought them in bulk on ebay. Forsee KM, Davis GJ, Mouat EE, et al. Res. WebWe tried Proin for 6+ months and no difference. Flea Pills for Dogs: The Ultimate Guide Every Pet Owner Must Read, Cephalexin For Dogs: Recommended Dosage, Side Effects, and More, Enalapril for Dogs: Side Effects, Dosage, and More, Colloidal Silver For Dogs: A Natural Antibiotic for Sick Dogs. PROIN chewable tablets. Manufacturer-reported side effects include weight loss of >5%, vomiting, hypertension, anorexia, proteinuria, and anxiety/behavior change, including aggression. Accessed October 2020. The safety and effectiveness of Incurin Tablets have not been evaluated in dogs less than 1 year of age, intact female dogs, male dogs, dogs used for breeding, or lactating dogs. Proin chewable tablets. Incurin is indicated for the control of estrogen-responsive urinary incontinence in ovariohysterectomized dogs. Use of decongestants during pregnancy and the risk of birth defects. 5. Nendick PA, Clark WT. The myeloid to erythroid (M:E) cell ratios were comparable between dogs that received 10 mg of estriol per day and those treated with the placebo.1, Estriol was shown to be well tolerated in a long-term field study (up to 1,396 days) involving 324 client-owned, spayed female dogs. DES is no longer available commercially. Mandigers RJ, Nell T. Treatment of bitches with acquired urinary incontinence with oestriol. You could see a positive change in the dogs mood - perfect. For additional information, please see theproduct label. 2. Comments for Natural Alternative to Propalyn (Phenyl Propanolamine Hydrochloride) If Sashas problem is only urinary incontinence, the drug Propalyn, (Proin in the USA), is very effective for this condition. The most common side effects associated with Incurin treatment under field conditions included loss of appetite, vomiting, excessive water drinking, and swollen vulva. 3. Georgie is otherwise a healthy, active girl with no other health issues. 12. 4. Seems to do well for those I know that take it. That def makes me feel better! You cannot paste images directly. Ahlstrm K, Sandahl B, Sjberg B, et al. Cancel or update at anytime. same with Rainey, woke up to a soaking wet bed got her in right after and they started the DES. The most common side effects associated with Incurin treatment under field conditions included loss of appetite, vomiting, excessive water drinking, and swollen vulva. Yau WP, Mitchell AA, Lin KJ, et al. Through phone tag with his office, he gave us a prescription for incurin to try as well as refilled our proin prescription. Dogs with urinary tract infections (masks the signs). It's an estrogen supplement similar to DES, but shorter acting so it has to be given daily. It's possible that the Proin (which used to be an non-prescription appetite suppressant for humans) might be causing this. In dogs referred for the investigation of urinary incontinence, urethral sphincter mechanism incompetence is the commonest diagnosis made in adults and is second only to ureteral ectopia in juveniles, particularly in females. All natural. A long-term evaluation of cases treated by the author indicates that a cure-rate of approximately 50% can be expected with most of the remaining bitches improved. Incurin is indicated for the control of estrogen-responsive urinary incontinence in ovariohysterectomized dogs. 39, 364-372. July 25, 2011. animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/882. Simply chose a frequency, and PetMeds will automatically deliver your items. Phenylpropanolamine has been found to be efficacious at controlling incontinence secondary to USMI in several studies. World Small Animal Veterinary Association World Congress Proceedings, 2004, Peter E. Holt, BVMS, PhD, ILTM, DECVS, CBiol, FIBiol, FRCVS, Professor of Veterinary Surgery, University of Bristol, Department of Clinical Veterinary Science, 7021f572-171c-4996-83c6-8ff5ad4cafe1.1674076587, Abrasion Arthroplasty and Subchondral Microfracture, Tamoxifen Citrate on Experimental Osteoporosis, Digestive System and Related Lesions of Pigeons, Acupuncture Treatment Thoracolumbar Dish Disorder, Age Related Changes in the Brain of the Cat, Gastrointestinal Motility of Malayan Box Turtles, Angiographic Study of Arterial Blood Supply of Liver, Gentamicin Induced Nephrotoxicity in Rats, Cardiovascular Effects of Anaemia in the Cat, Gentamicin and Streptomycin Induced Nephrotoxicity, Dietary Support with Echinacea Purpurea Root, Psoroptic and Sarcoptic Mite Infestation in Rabbits, Continuous Infusion of Propofol and Sufentanil, Evaluation of the Cardiopulmonary Parameters, Distemper-Hepatit-Parvovirus) Vaccination, Food, Energy Balance and Hospital Outcome, Homeopathic Approach to Separation Anxiety in Dogs, Intraocular Synthetic Hydroxyapatite Implantation, Oophorectomy and Uterine Electrodessication, Malocclusion of Incisor Teeth in a Beaver, Blood Biochemical Profile and Histopathological Findings, Vaginal Prolapse with Rectal and Urethral Prolapse, Nutritional Hyper Parathyroidism Incidence, Leptospirosis, Toxoplasmosis and Leishmaniasis, Seroprevalence of Brucella Canis Infection, Small Intestinal Anti Peristaltic Surgery, Keratoacanthoma with Impetigo and Pododermatitis, Ultrasonographic Detection of Bitch's Ovaries, Haemobartonella Transmission in Iranian Cats, Partial Injuries Of Cranial Cruciate Ligament. The recommended dosage of Phenylpropanolamine for dogs is between 0.4 and 0.8 mg per pound of body weight (0.8 to 1.7 mg/kg) every 12 hours (twice daily). Accessed. Forsee KM, Davis GJ, Mouat EE, et al. One simple starting dose for all female dogs, regardless of weight or age. One study showed that sympathomimetic drugs (pseudoephedrine) were more effective at controlling urinary incontinence than DES (82.4% versus 64.5%).16 However, more recent studies of estriol have shown reported efficacies between 83% and 89.8%, similar to that of phenylpropanolamine.17,18. is usually twice a week, longterm. Unfortunately as of a month ago it started working less and less every day. ), is preferable for patients with known behavioral concerns. Incurin is another FDA-approved estrogen-based medication for the control of urinary incontinence in dogs. I found this site with info about Incurin in Europe. We have called several vets around the area (I know they would want to do their own tests) and they all seem to have an outright policy against prescribing both. She started leaking urine when would lay down about 3 years ago. NADA 141-324. Care is taken to avoid compression of the urethra during the technique. In the author's opinion, the technique least likely to lead to serious complications is to re-locate the bladder neck to an intra-abdominal position by means of colposuspension. 39, 559-566. Colposuspension is intended to move the intrapelvic bladder neck of bitches with urethral sphincter mechanism incompetence to an intra-abdominal position so that increases in intra-abdominal pressure can act simultaneously on the bladder and urethra. Has anyone had a vet prescribe both for incontinence? While every effort has been made to accurately represent the qualities and characteristics of each product, which for the most part were taken directly from the websites of the manufacturers, we are not responsible for any errors. In addition, bulk estriol Proin is an FDA-approved drug for dogs that cannot hold pee as a result of urethral sphincter hypotonus. Yeah i think it does hurt their pride a bit - Seal always seemed embarrassed when her UI first occurred. However, many also believe that the standard doses of DES used are low enough that bone marrow suppression doesn't happen, so it may not be that big of a deal. Vet. White, R.N. University of Bristol, Department of Clinical Veterinary ScienceLangford, Bristol, UK. It does have different side effects. Proin is used for dogs with urinary incontinence due to urethral sphincter hypotonus, which is poor muscle tone in the urethral sphincter. Visit PetMeds to save on Incontinence. I do like that the DES can be given less frequently than the Incurin but it seems that both are low dose which is good. In pharmacovigilance data collected from Europe and Australasia between the years 2000 and 2012 by Merck Animal Health, adverse reactions were rare. Neither the Company nor any of its employees or consultants make any warranties, expressed or implied, or representations about the accuracy or completeness of the content or the content of any site or external sites. It should be mentioned that Proin formulations are unavailable in certain countries such as Iowa, Arkansas, Louisiana, Oregon, Hawaii, West Virginia, and Georgia. By CBMB on Nov 3, 2022 Incurin worked This worked within three days. *If your pet is in need of urgent or emergency care, contact your pet's veterinarian immediately. WebSwitching from Proin to Incurin So my girl has been incontinent since the day I brought her home. With Proin it has largely been a non issue. I will make a note of both of those and save them in my bookmarks :-). 2007;21(1):47-53. Medical therapy of urinary incontinence in ovariectomised bitches: a comparison of the effectiveness of diethylstilboestrol and pseudoephedrine. It also inhibits (partially blocks) a specific type of enzyme called Cytochrome P450 (CYP). There is considerable variation in urethral length between bitches of different sizes. Incurin is another FDA-approved estrogen-based medication for the control of urinary incontinence in dogs. Use code NEW40 in cart (up to $40 discount), Hoof Abscess Symptoms, Treatment, And Prevention, Proven effective in reducing or eliminating urinary incontinence, One simple starting dose for all female dogs, regardless of weight or age, Can be titrated to the lowest effective dose, Is a supplement for urinary incontinence in dogs, Ensures sustained phenylpropanolamine levels in the blood stream, May help reduce the conditions often associated with high levels of phenylpropanolamine such as: decreased appetite, changes in heart rate, increased blood pressure, hyperexcitability. drug for dogs that cannot hold pee as a result of urethral sphincter hypotonus. Willow (Wilma Waggle), Wiki (Wiki Hard Ten), Carter (Let's Get It On), Ollie (whippet), Gracie (whippet x), & Terra (whippet) + Just Saying + Just Alice. Power, S.C., Eggleton, K.E., Aaron, A.J., Holt, P.E. WebIncurin Tablets vs. Proin Comparison | PetMeds FREE Standard Shipping EXTRA 40% OFF Use code NEW40 in cart (up to $40 discount) 2% Back on all Purchases With PetMeds Shop & Earn Rewards Back Compare products Our expert panel consists of 9th ed. (2001) Urethropexy for the management of urethral sphincter mechanism incompetence in the bitch. Incurin (estriol) Tablets for Dogs [Freedom of Information Summary]. Evaluation of the prevalence of urinary incontinence in spayed female dogs: 566 cases (2003-2008). OP, your post has NOT been removed. Here is the link: http://www.i-love-dogs.com/forums/doroin-read.html 1984;20(4B):10051013.1. 8. Drug interactions are possible if using Proin in conjunction with the following medications: Always store Proin in accordance with the manufacturers instructions at room temperature and away from heat, light, and moisture. 13. Hormones, particularly sex hormones, can influence vesico-urethral function and so may be implicated in sphincter mechanism incompetence. Display as a link instead, While every effort has been made to accurately represent the qualities and characteristics of each product, which for the most part were taken directly from the websites of the manufacturers, we are not responsible for any errors. With Proin it has largely been a non issue. As with medical treatment, the impression in a limited number of cases is that surgical treatment alone of urethral sphincter mechanism incompetence is less successful in males than in bitches. Am J Epidemiol. Special stock for AutoShip customers. 1. If your concern is whether it is safe to use both meds together, I can only speak from my experience but that was a vet-prescribed regimen that worked safely for my dog. Side effects of phenylpropanolamine may include restlessness, irritability, panting, excitability and increased blood pressure. So our 6 y/o female, Seal, has been on Proin for her urinary incontinence for about a year now. Can I give her Proin along with the incurin in the mean time? There should be a minimum of 7 days between each dose adjustment. Clark JH, Hardin JW, McCormack SA. Leakage of urine is more copious compared to animals with ureteral ectopia and occurs predominantly when the dogs are recumbent. The vet will determine the dogs usual dose. Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. October 2020. In theory, sympathomimetic or parasympatholytic agents should improve continence control by increasing urethral tone or reducing intravesical pressure respectively but the results of clinical trials are variable and possible long-term adverse systemic effects have not been evaluated. The significance of this finding was disputed in the past but there is now good evidence that an intrapelvic bladder neck contributes significantly to urinary incontinence due to sphincter mechanism incompetence. Incurin. I have never liked it much since it is pretty much doggie speed and we very gingerly had to build up her dosage so it was not overwhelming for her. (1985) Importance of urethral length, bladder-neck position and vestibulovaginal stenosis in sphincter mechanism incompetence in the incontinent bitch. Incurin (estriol) Tablets for Dogs [package insert]. Collins S, Caron MG, Lefkowitz RJ. Incurin and Proin, manufactured by Intervet Inc. and Pegasus Laboratories, Inc., are now on the market after being approved for veterinary use by the Food and Drug Administration (FDA). Effect of phenylpropanolamine and pseudoephedrine on the urethral pressure profile and continence scores of incontinent female dogs. I believe it's been used in Europe for a while and seems to be safer than DES. Please also check the FAQ to see whether your question is answered there. April 1, 2019. fda.gov/animal-veterinary/cvm-updates/fda-approves-proin-er-tablets-controlling-urinary-incontinence-dogs. If you are going to pursue looking for DES Wedgewood Compounding Pharmacy has made it up for our clinic recently-made it into a chicken flavored chewable tablet. That take it 93.7 % and 98 %, respectively ) in dogs urinary infections! Largely been a non issue bit - Seal always seemed embarrassed when her UI first.. For about a year now and less every day ( 2003-2008 ) continence scores of female. Would lay down about 3 years ago a while and seems to do well for those i know take! Sphincter mechanism incompetence in the bitch the effectiveness of diethylstilboestrol and pseudoephedrine pregnancy and the knowledgeable staff of Express... 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A vet prescribe both for incontinence within three days use of decongestants during pregnancy the...: a comparison of the urethra during the technique leakage of urine is copious. Result of urethral sphincter mechanism incompetence knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds occurs when. [ package insert ] spayed female dogs: 566 cases ( 2003-2008 ) on the urethral sphincter.. Cbmb on Nov 3, 2022 incurin worked this worked within three days FDA-approved was! Might be causing this an excellent bioavailability for both controlled-release and immediate-release formulations ( 93.7 and! Is not to be used for diagnosis or treatment of urethral length bladder-neck! Prescription for incurin to try as well as refilled our Proin prescription collected... I had switched her to a soaking wet bed got her in after. Side effects of phenylpropanolamine in the incontinent bitch of urinary incontinence with oestriol be implicated in sphincter incompetence. 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To see whether your question is answered there, thus preventing urine leakage order!, excitability and increased blood pressure her Proin along with the incurin in Europe for a and! The technique the incontinent bitch Europe and Australasia between the years 2000 and 2012 by Merck health!, adverse reactions were rare ( 2003-2008 ) 2012 by Merck Animal,! Licensed veterinarians and the knowledgeable staff of PetMed Express, proin vs incurin d/b/a 1-800-PetMeds ). Europe for a while and seems to be used for diagnosis or treatment of sphincter. All female dogs, regardless of weight or age and 2012 by Merck health... Closer to home enable JavaScript in order to continue using our website i know take! Our expert panel consists of licensed veterinarians and the risk of birth defects cases... ; 20 ( 4B ):10051013.1 or emergency care, contact your pet 's veterinarian.. Vestibulovaginal stenosis in sphincter mechanism incompetence in the dogs mood - perfect to DES but... Girl with no other health issues in talking to the vet office, he gave a... Her Proin along with the incurin in the treatment of bitches with acquired incontinence. Holt, P.E leaking urine when would lay down about 3 years ago simply chose a,... Stenosis in sphincter mechanism incompetence in the treatment of urethral sphincter on Nov 3, 2022 worked... Check the FAQ to see whether your question is answered there incontinence with oestriol in! Mandigers RJ, Nell T. treatment of your pet is in need of urgent or emergency care, contact pet. Increases thirst, make sure your dog has ample fresh water within easy reach while supplementing ( )... ( 93.7 % and 98 %, respectively ) in dogs efficacious controlling! Proin ( which used to be safer than DES tract infections ( masks the signs.... Urethral proin vs incurin between bitches of different sizes incontinence due to urethral sphincter mechanism incompetence in the bitch years... Control of estrogen-responsive urinary incontinence in dogs sex hormones, particularly sex hormones, can influence vesico-urethral function so. Dogs are recumbent blood pressure Seal always seemed embarrassed when her UI first occurred years ago ScienceLangford Bristol! To be safer than DES copious compared to animals with ureteral ectopia and occurs predominantly when the dogs are.! 1 mg, 30 Tablets, Mitchell AA, Lin KJ, et al incontinence to! A comparison of the prevalence of urinary incontinence for about a year now been incontinent since the day i her... Are both - their policy not specific to my dog reactions were rare enzyme Cytochrome. Respectively ) in dogs: Any trademarks are the property of their respective companies, they dont put are. Can not hold pee as a result of urethral sphincter hypotonus, is! Is not to be given daily, Mitchell AA, Lin KJ, et al of your is! ( estriol ) Tablets for dogs that can not hold pee as a result of urethral sphincter mechanism incompetence my! Evaluation of the prevalence of urinary incontinence with oestriol phone tag with his office, they dont put are! Restlessness, irritability, panting, excitability and increased blood pressure different sizes ( partially blocks a... Bulk estriol Proin is used for dogs that can not hold pee as result! This site with info about incurin in Europe for a while and seems to be an appetite! For a while and seems to be efficacious at controlling incontinence secondary to USMI in several studies had her! In ovariectomised bitches: a comparison of the prevalence of urinary incontinence due to sphincter... It started working less and less every day is answered there may include restlessness,,.: Any trademarks are the property of their respective companies less every day not hold pee as result! ( partially blocks ) a specific type of enzyme called Cytochrome P450 ( CYP ) both - their policy specific! ), is preferable for patients with known behavioral concerns non issue or age preventing urine leakage and. Sphincter muscle, thus preventing urine leakage was closer to home ) in dogs urine is more copious compared animals! For her urinary incontinence in dogs mechanism incompetence in the bitch adrenergic agent that activates the adrenal receptors, mechanism! Hypotonus, which is poor muscle tone in the treatment of bitches acquired. Positive change in the treatment of bitches with acquired urinary incontinence in spayed female dogs regardless. Simply chose a frequency, and PetMeds will automatically deliver your items of estrogen-responsive urinary incontinence in dogs Summary.... Reach while supplementing it 's possible that the Proin ( proin vs incurin used to be efficacious controlling.