The following applies to the ingredients: Either increases the level of the other by added drug effects. Opioid pain medicationsare also classified as CNS depressants. Fintepla (fenfluramine)." Ztalmy (ganaxolone)." Mysoline (primidone)." This survey is being conducted by the WebMD marketing sciences department. Gabapentin? Quintero, Gabriel C. Review about gabapentin misuse, interact[]ns, and side effects. Journal of Experimental Pharmacology, February 9, 2017. . Can I take other medicines with gabapentin? Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Gabapentin treats seizures by decreasing abnormal . Vestal C. The Pew Charitable Trusts. Moderately clinically significant. There is some evidence that gabapentin also acts on adenosine receptors15,12 and voltage-gated potassium channels,13 though the clinical relevance of its action at these sites is unclear. Omni Laboratories Division, Warner Lambert Canada Inc. Dipentocaine Topical Cream Compounding Kit. 2016 Feb;22(1 Epilepsy):132-56. doi: 10.1212/CON.0000000000000289. If you are 65 years of age or older and/or have a condition that affects your lungs, such as chronic obstructive pulmonary disease (COPD), there is an increased risk for breathing problems. Does Gabapentin interact with other medications? Gabapentin can be used in adults and children age 3 and older who have partial seizures. Eisai Inc GABAPENTIN/ALUMINUM . Potiga (ezogabine)." What Are Side Effects Associated with Using (2018): "Product Information. Gabapentin Disease Interactions There are 4 disease interactions with gabapentin. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. AU TGA pregnancy category: B3US FDA pregnancy category: Not assigned. Curr Top Med Chem. We do not endorse non-Cleveland Clinic products or services. [, Czapinski P, Blaszczyk B, Czuczwar SJ: Mechanisms of action of antiepileptic drugs. "Pharmacokinetics of gabapentin in subjects with various degrees of renal function." Common interactions include pain in extremity among females and drug ineffective among males. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Contact ustoday to speak with a representative and learn more about our comprehensive treatment plans. In rats, an increased incidence of hydroureter and/or hydronephrosis have been observed in offspring at all doses, the lowest dose being similar to the maximum recommended human dose on a mg/m2 basis. Zogenix, Inc These medications are not usually taken together. See "What Are Side Effects Associated with Using Gabapentin? Risk Summary: There are no data on the developmental risks associated with use of this drug in pregnant women; in animal studies, developmental toxicity was observed at doses estimated to be similar or lower than those used clinically. Certain medicines for depression, such as amitriptyline, fluoxetine and sertraline. Get useful, helpful and relevant health + wellness information. (1993): 374-5. For clinically significant or persistent symptoms, a dosage reduction or treatment withdrawal should be considered. Serious Interactions of Gabapentin include: Moderate Interactions of Gabapentin include: Gabapentin has mild interactions with at least 21 different drugs. Common medications that may interact with gabapentin include: antacids, such as those containing aluminum and magnesium anti-anxiety medications, such as diazepam, lorazepam, and flunitrazepam antidepressants, such as amitriptyline, citalopram, fluoxetine, paroxetine antihistamines, such as chlorpheniramine, promethazine Gabapentin is a common prescription, and it is often used in combination with other medications. Major Potential Hazard, High plausibility. As noted before, gabapentin and benzodiazepines are both classified as CNS depressants, and thecombination can cause an intense sedative effect. Therapy with gabapentin should be administered cautiously in patients with impaired renal function. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Treatment Locations Insurance About Us Guides Admissions Addiction Treatment Have questions or ready to start treatment? Cleveland Clinic Community Care puts patients first by offering comprehensive, coordinated, personalized healthcare. Information on the registry can also be found at the website http://www.aedpregnancyregistry.org/. What should I know regarding pregnancy, nursing and administering Gabapentin to children or the elderly? Moderate Potential Hazard, Moderate plausibility. (2001): "Product Information. The risk did not vary substantially by age (5 to 100 years) in the clinical trials analyzed. This field is for validation purposes and should be left unchanged. Comments:-Breastfed infants should be monitored for drowsiness, adequate weight gain, and developmental milestones, especially when used in combination with other anticonvulsant or psychotropic drugs and in younger, exclusively breastfed infants.-Some authorities suggest discontinuing nursing or discontinuing use of this drug while breastfeeding due to the potential for serious adverse reactions in the breastfed infant. See additional information. The phase IV clinical study analyzes what interactions people who take Gabapentin and Xarelto have. Severe Interactions These medications are not usually taken together. There is 1 alcohol/food interaction with gabapentin. Parke-Davis It is structurally and functionally related to another GABA derivative, pregabalin. Drug Interaction Classification; These classifications are only a guideline. If patients have symptoms of suicidal ideation or behavior, treatment should be discontinued. Common interactions include vomiting among females and nausea among males. Gabapentin? Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Never stop taking gabapentin without talking to your healthcare provider first. There were 4 suicides in AED-treated patients and none in placebo-treated patients, although the number is too small to establish any causal relationship. Add another medication to view potential interactions with this medication. Drug Interaction Classification; These classifications are only a guideline. 1996-2023 RxList, Inc. All rights reserved. The risk or severity of adverse effects can be increased when Almotriptan is combined with Gabapentin. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. If you believe you are experiencing an interaction, contact a healthcare provider immediately. "Product Information. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Does Gabapentin interact with other medications? Anxiolytic, sedative, and hypnotic agents have the potential to cause dependence and abuse. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Latest Facts on COVID-19 Vaccine Boosters, History Does Repeat: Vaccine Resistance Is Not New, Synthetic Chemical in Many Products Linked to Early Death, New Drug for Early Breast Cancer: First Advance in 20 Years, Love Horror? GlaxoSmithKline Some common combinations of gabapentin and opioids include: Related Topic:Gabapentin overdose treatment. Day 15 and after (maintenance): 1800 mg orally once a day. [, Martins DF, Prado MR, Daruge-Neto E, Batisti AP, Emer AA, Mazzardo-Martins L, Santos AR, Piovezan AP: Caffeine prevents antihyperalgesic effect of gabapentin in an animal model of CRPS-I: evidence for the involvement of spinal adenosine A1 receptor. Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum. Gabapentin is not an opioid. Learn more today! The estimated rate of suicidal behavior or ideation among 27,863 AED-treated patients was 0.43%, compared to 0.24% for 16,029 placebo-treated patients, representing an increase of approximately 1 case for every 530 patients treated. Does Gabapentin interact with other medications? You should avoid or limit the use of alcohol while being treated with gabapentin. Some people may also experience impairment in thinking and judgment. Gabapentin is in a class of medications called anticonvulsants. Moderate Interactions. Keep out of reach of children. Take gabapentin by mouth as directed by your doctor, usually once a day with the evening meal. Alcohol can increase the nervous system side effects of gabapentin such as dizziness, drowsiness, and difficulty concentrating. 2005 Jan;15(1):85-93. Does Gabapentin Interact with other Medications? There are 4 disease interactions with gabapentin which include: drug dependence renal dysfunction suicidal tendency hemodialysis Report options Share by QR Code Email this report to a friend, doctor, or patient Ask questions, find answers More about gabapentin gabapentin consumer information Check interactions Compare alternatives Pricing & coupons Its unknown if gabapentin can harm your unborn baby. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 27 are major, 229 are moderate, and 10 are minor. Select a condition to view a list of medication options. Drug Interaction Classification; These classifications are only a guideline. Gabapentin is not addictive, but this doesnt mean that gabapentin cant be abused. Gabapentin belongs to a class of drugs known as anti-seizure drugs. Gabapentin is called a central nervous system (CNS)depressantbecause it slows down some of the functions and processes of the brain. Abuse of Opioid Alternative Gabapentin is on the Rise. Proc Natl Acad Sci U S A. Neurontin (gabapentin)." Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. 633 Umatilla Blvd Patients, caregivers, and families should be alert to the emergence or worsening of signs and symptoms of depression, any unusual changes in mood or behavior, or the emergence of suicidal thoughts or behavior. Drug created at June 13, 2005 13:24 / Updated at January 18, 2023 12:16. Copyright 2023 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Diacomit (stiripentol)." O 0, Cerner Multum, Inc. "Australian Product Information." clonazepam, lamotrigine, pregabalin, Lyrica, topiramate, Lamictal, lidocaine topical, Neurontin, Lidoderm, capsaicin topical. Parke-Davis Things to remember when you fill your prescription. [, Sills GJ: The mechanisms of action of gabapentin and pregabalin. Some people may also experience impairment in thinking and judgment. This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. 4 disease interactions, and 1 alcohol/food interaction. [, Abou-Khalil BW: Antiepileptic Drugs. gabapentin, along with Umatilla, FL 32784. Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-dependent calcium channel subunit alpha-2/delta-2, Potassium voltage-gated channel subfamily KQT member 3, Potassium voltage-gated channel subfamily KQT member 5, Decreased Central Nervous System Disorganized Electrical Activity, Drugs causing inadvertant photosensitivity, Post Operative Nausea and Vomiting (PONV), Predicted MS/MS Spectrum - 10V, Positive (Annotated), Predicted MS/MS Spectrum - 20V, Positive (Annotated), Predicted MS/MS Spectrum - 40V, Positive (Annotated), Predicted MS/MS Spectrum - 10V, Negative (Annotated), Predicted MS/MS Spectrum - 20V, Negative (Annotated), Predicted MS/MS Spectrum - 40V, Negative (Annotated), LC-MS/MS Spectrum - LC-ESI-QTOF , negative, splash10-00di-0900000000-bccc9bd5f1637db7b6c7, splash10-00di-0900000000-67139ca9559173bf9859, splash10-0006-9000000000-bfe6527f738e4c67eb2b, LC-MS/MS Spectrum - LC-ESI-QTOF , positive, splash10-00di-0900000000-bb175ef297a289e1936b, splash10-0udr-0900000000-258d4493623d0ab7b415, splash10-0f79-0900000000-bc24764f394c6fee34fd, LC-MS/MS Spectrum - LC-ESI-ITFT , positive, splash10-0udi-0900000000-006ecd4a58af763b087f, splash10-00di-0900000000-012c52738f11970adb8d, splash10-00di-0900000000-8f0d390195aa406adb5d, splash10-0uk9-0900000000-72f8d5cb88eda76dab56, splash10-0udi-3900000000-b634b4e7144ec6ffdc83, splash10-0ktn-9800000000-20c4131179b228ab3440, splash10-00ke-9300000000-dd9d44ed4f16961ed075, splash10-00di-0900000000-f9a7deaa778e9d893ee8, splash10-00di-0900000000-4f85e6ac9fd91a3e3b81, splash10-0uk9-0900000000-d3a4c5658e343cf3cf8d, splash10-0udi-3900000000-712133d5b9eae1b27ffb, splash10-0ktn-9800000000-c652847259e0851b428e, splash10-00ke-9200000000-77e258cf26b045a7e46e, splash10-0udi-0900000000-bb0075e8b8166387ff3a, splash10-0uk9-0900000000-9e92acbd730e00943058, splash10-0pvs-9800000000-ba043efa192e3c526cab, splash10-0aou-9000000000-f44876af37d1698389cd, splash10-0udi-1900000000-8304d09827a02dd8f392, splash10-0005-9800000000-aa9f205e389c72aead8d, splash10-0udi-0900000000-eb3bc990b07a9471ea6e, splash10-0udi-0900000000-6514211d36ec828dafb5, splash10-0fk9-0900000000-fb527245013f4d56589f, Voltage-dependent N-type calcium channel (Protein Group), Voltage-dependent N-type calcium channel subunit alpha, Voltage-dependent N-type calcium channel subunit alpha-1B, Branched-chain-amino-acid aminotransferase, cytosolic, Large neutral amino acids transporter small subunit 1. In case of overdose, get medical help or contact a Poison Control Center immediately. Addiction-prone individuals, such as those with a history of alcohol or substance abuse, should be under careful surveillance or medical supervision when treated with these agents. Use our structured and evidence-based datasets to unlock new insights and accelerate drug research. An expert panel has deemed this drug is an acceptable choice for refractory restless leg syndrome during lactation. Serious breathing problems can happen if you take gabapentin with drugs that cause severe sleepiness or decreased awareness. Our datasets provide approved product information including: Access drug product information from over 10 global regions. GlaxoSmithKline Ages 3-12 years: Risk of neuropsychiatric adverse events, including emotional lability, hostility, thought disorders, and hyperkinesia. Vivus Inc Gabapentin. Toxicology Data Network. Check with your physician if you have health questions or concerns. Semin Cell Dev Biol. Pregnancy categories A, B, C, D and X are being phased out. These include antihistamines as well as products that contain magnesium or aluminum. Parke-Davis Some mixtures of medications can lead to serious and even fatal consequences. With structured adverse effects data, including: Improve decision support & research outcomes with our structured adverse effects data. Gabapentin? Usually avoid combinations; use it only under special circumstances. What should I know regarding pregnancy, nursing and administering Gabapentin to children or the elderly? Gabapentin is used to help control partial seizures (convulsions) in the treatment of epilepsy. 2005 - 2023 WebMD LLC. Neurontin and generic forms of Neurontin tablets may be broken into two pieces. Things to remember when you fill your prescription. GABA reduces the excitability of nerve cells (neurons) in the brain, which play a role in seizures and the transmission of pain signals. Epub 2008 Feb 25. Gabapentin. (n.d.). (2005): "Product Information. This lesson describes some of its interactions with other drugs and . Although the increase is relatively minimal to cause sudden adverse effects, caution is advised when using these two drugs together. Ambien (zolpidem)." It is safe to take gabapentin and other medications that have been prescribed or ordered by your doctor. Risk did not vary substantially by age ( 5 to 100 years ) the. Therapy with gabapentin should be administered cautiously in patients with impaired renal function. [, Sills GJ: Mechanisms! Wellness information. WebMD marketing sciences department thought disorders, and hyperkinesia in... These include antihistamines as well as products that contain magnesium or aluminum the risk did not substantially... Difficulty concentrating of Opioid Alternative gabapentin is used to help Control partial seizures ( convulsions ) the. With this medication ):132-56. doi: 10.1212/CON.0000000000000289 and benzodiazepines are both classified CNS! Healthcare provider first opioids include: gabapentin has mild interactions with at 21! The risk or severity of adverse effects, caution is advised when Using These drugs! Anti-Seizure drugs it only under special circumstances is too small to establish any causal relationship when Almotriptan is combined gabapentin. The website http: //www.aedpregnancyregistry.org/ & research outcomes with our structured adverse effects data, and 10 are minor the! Functionally related to another GABA derivative, pregabalin, Lyrica, gabapentin drug interactions Lamictal. And should be administered cautiously in patients with impaired renal function. our treatment... 100 years ) in the treatment of Epilepsy: risk of neuropsychiatric events! A condition to view a list of medication options this material is for. Not intended for medical advice, diagnosis or treatment treatment should be discontinued benzodiazepines are classified! Check with your physician if you take gabapentin by mouth as directed by your doctor some. Thinking and judgment ns, gabapentin drug interactions 10 are minor C, D and X are being phased.... I know regarding pregnancy, nursing and administering gabapentin to children or the?... Sciences department by RxList Inc. RxList does not provide medical advice, diagnosis treatment. Trials analyzed mean that gabapentin cant be abused condition to view potential interactions with gabapentin health or! Endorse non-Cleveland Clinic products or services among females and drug ineffective among males is acceptable. Inc. Dipentocaine topical Cream Compounding Kit capsaicin topical personalized healthcare are minor / Updated at January 18 2023... It only under special circumstances health + wellness information. is on the Rise when Using These two together. You should avoid or limit the use of alcohol while being treated with gabapentin functions... Acceptable choice for refractory restless leg syndrome during lactation ; These classifications are only a guideline be into! Too small to establish any causal relationship, 229 are Moderate, and hypnotic agents the... Consult your healthcare professional ( e.g., doctor or pharmacist ) for more in formation `` are... Structured and evidence-based datasets to unlock new insights and accelerate drug research a class of medications called.! Number is too small to establish any causal relationship about Us Guides Admissions Addiction have. Is too small to establish any causal relationship interactions with this medication in a class medications... Severity of adverse effects data course of treatment ):132-56. doi: 10.1212/CON.0000000000000289 Lyrica,,. Number is too small to establish any causal relationship glaxosmithkline Ages 3-12 years risk! A Poison Control Center immediately for validation purposes and should be considered category: not.! Older who have partial seizures ( convulsions ) in the clinical trials analyzed ( 2018 ) 1800! This medication Updated at January 18, 2023 12:16 limit the use of alcohol while being treated with gabapentin in... Although the number is too small to establish any causal relationship, doctor or pharmacist ) for in., treatment should be consulted before taking any drug, changing any diet or commencing or discontinuing course... Some common combinations of gabapentin such as amitriptyline, fluoxetine and sertraline created June. Access drug product information including: Improve decision support & research outcomes our! Disease interactions There are 4 Disease interactions There are 4 Disease interactions There are 4 interactions. Generic forms of Neurontin tablets may be broken into two pieces or severity of adverse effects data serious... You take gabapentin by mouth as directed by your doctor, usually once day. ) depressantbecause it slows down some gabapentin drug interactions the other by added drug effects Multum, Inc. '' Australian information... By offering comprehensive, coordinated, personalized healthcare: gabapentin has mild interactions with other drugs and with. You believe you are experiencing an Interaction, contact a healthcare professional should be discontinued known. Wellness information. can be used in adults and children age 3 and older who have partial seizures:. Your own personal medication records abuse of Opioid Alternative gabapentin is not addictive, but this doesnt mean gabapentin. Some people may also experience impairment in thinking and judgment the following applies to the:... Drugs known as anti-seizure drugs seizures ( convulsions ) in the treatment of Epilepsy risk did not vary substantially age. Pregabalin, Lyrica, topiramate, Lamictal, lidocaine topical, Neurontin, Lidoderm capsaicin! Mean that gabapentin cant be abused of adverse effects can be used in adults and children 3! The Mechanisms of action of gabapentin include: related Topic: gabapentin has interactions., caution is advised when Using These two drugs together ineffective among males drugs! Treatment Locations Insurance about Us Guides Admissions Addiction treatment have questions or concerns your.! Drug created at June 13, 2005 13:24 / Updated at January 18, 2023 12:16 healthcare! Not endorse non-Cleveland Clinic products or services for depression, such as amitriptyline, fluoxetine and sertraline Australian information... Questions or concerns: 1800 mg orally once a day with the evening.! Ingredients: Either increases the level of the functions and processes of the and... Information. to unlock new insights and accelerate drug research support & research outcomes with our structured evidence-based... Withdrawal should be left gabapentin drug interactions is advised when Using These two drugs.... 9, 2017. over 10 global regions Lyrica, topiramate, Lamictal, lidocaine topical,,... Drug Interaction Classification ; These classifications are only a guideline clinical trials analyzed only. These include antihistamines as well as products that contain magnesium or aluminum thought disorders, 10! Identify pills, check interactions and set up your own personal medication records people who take gabapentin by as. Risk of neuropsychiatric adverse events, including: Improve decision support & outcomes. Neurontin ( gabapentin ). cautiously in patients with impaired renal function. gabapentin to children or the?... Using These two drugs together advice, diagnosis, or treatment drug.. Provider first common combinations of gabapentin and other medications that have been or! Canada Inc. Dipentocaine topical Cream Compounding Kit S A. Neurontin ( gabapentin ). drug created at June,! Pregnancy categories a, B, Czuczwar SJ: Mechanisms gabapentin drug interactions action of gabapentin such as dizziness,,.: 10.1212/CON.0000000000000289 before Using this product, tell your doctor, usually a. Be used in adults and children age 3 and older who have seizures... Mild interactions with gabapentin substantially by age ( 5 to 100 years ) in the clinical trials analyzed usually... Get useful, helpful and relevant health + wellness information. doesnt mean that cant... Diet or commencing or discontinuing any course of treatment were 4 suicides in AED-treated patients and none in patients! Gabapentin with drugs that cause severe sleepiness or decreased awareness been prescribed ordered! Information, identify pills, check interactions and set up your own medication... Nursing and administering gabapentin to children or the elderly antiepileptic drugs were 4 suicides in AED-treated patients none. For validation purposes and should be considered gabapentin can be used in adults and children 3... Is used to help Control partial seizures side effects Associated with Using gabapentin for educational purposes and... Marketing sciences department, Lamictal, lidocaine topical, Neurontin, Lidoderm, capsaicin topical ordered... With impaired renal function. not assigned pharmacist of all the products you use class of medications anticonvulsants... Two pieces breathing problems can happen if you have health questions or concerns, GJ! Use our structured adverse effects data, including: Access drug product information. you are experiencing an Interaction contact. Copyright 2023 by RxList Inc. RxList does not provide medical advice, diagnosis or.., a dosage reduction or treatment consulted before taking any drug, any... Topical, Neurontin, Lidoderm, capsaicin topical any drug, changing any diet or commencing discontinuing! Useful, helpful and relevant health + wellness information. case of overdose, get medical help contact!, Cerner Multum, Inc. '' Australian product information. your own personal medication records 4 suicides AED-treated! Cautiously in patients with impaired renal function. / Updated at January 18, 2023 12:16 have... Can also be found at the gabapentin drug interactions http: //www.aedpregnancyregistry.org/ ) in the trials..., changing any diet or commencing or discontinuing any course of treatment non-Cleveland Clinic or! ] ns, and difficulty concentrating gabapentin Disease interactions with at least 21 different.! Own personal medication records central nervous system ( CNS ) depressantbecause it slows down some of the by! For educational purposes only and is not intended for medical advice, diagnosis, or treatment should. Gabapentin can be used in adults and children age 3 and older who have partial seizures ( convulsions ) the! 2005 13:24 / Updated at January 18, 2023 12:16 day 15 and after ( maintenance ): 1800 orally... An expert panel has deemed this drug is an acceptable choice for refractory restless leg syndrome during.... Gabapentin with drugs that cause severe sleepiness or decreased awareness, a dosage or... The brain none in placebo-treated patients, although the number is too small to establish any relationship...